1 bottle of Care plus 

1 Bottle Care Plus 90

Indications and Usage for Promethazine and Codeine

Promethazine with Codeine Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold in patients 18 years of age and older.

Important Limitations of Use

• Not indicated for pediatric patients under 18 years of age.
• Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, reserve Promethazine with Codeine Oral Solution for use in adult patients for whom the benefits of cough suppression are expected to outweigh the risks, and in whom an adequate assessment of the etiology of the cough has been made.

Promethazine and Codeine Dosage and Administration

• Adults 18 years of age and older : 5 mL every 4 to 6 hours as needed, not to exceed 6 doses (30 mL) in 24 hours.
• Measure Promethazine with Codeine Oral Solution with an accurate milliliter measuring device.
• Do not increase the dose or dosing frequency.
• Use for the shortest duration consistent with treatment goals.
• Reevaluate condition with unresponsive cough in 5 days or sooner for possible underlying pathology.
• Reevaluate condition prior to refilling.

Dosage Forms and Strengths

Oral solution: Each 5 mL contains codeine phosphate, 10 mg and promethazine hydrochloride 6.25 mg in a flavored syrup base.