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Scientists have gleaned new insights into how psychedelics alter conscious experience via their action on brain activity.

In a study at Imperial College London, detailed brain imaging data from 20 healthy volunteers revealed how the potent psychedelic compound, DMT (dimethyltryptamine), alters brain function.

During the immersive DMT experience there was increased connectivity across the brain, with more communication between different areas and systems.

The changes to brain activity were most prominent in areas linked with ‘higher level’ functions, such as imagination and creativity.

"This work is exciting as it provides the most advanced human neuroimaging view of the psychedelic state to-date." Dr Chris Timmermann Centre for Psychedelic Research

DMT is a potent psychedelic found naturally in certain plants and animals. It occurs in trace amounts in the human body and is the major psychoactive compound in ayahuasca – the psychedelic brew prepared from vines and leaves and used in ceremonies in south and central America.

The study, published in the journal  PNAS , is the first to track brain activity before, during and after the DMT experience in such detail.

Dr Chris Timmermann , from the  Centre for Psychedelic Research  at Imperial College London, and first author on the study, said: “This work is exciting as it provides the most advanced human neuroimaging view of the psychedelic state to-date.

“One increasingly popular view is that much of brain function is concerned with modelling or predicting its environment.

Humans have unusually big brains and model an unusually large amount of the world. For example, like with optical illusions, when we’re looking at something, some of what we’re actually seeing is our brain filling in the blanks based on what we already know or have been told. 

What we have seen with DMT is that activity in highly evolved areas and systems of the brain that encode especially high-level models become highly stimulated under the drug, and this relates to the intense drug ‘trip’.”